In a previous post I mentioned that I was having difficulty attaching either one of my shutter releases to the 3x4 Grapfic. (Turns out they where to 'fat'.) Looking at the camera again I took off the lens and verified what I had been told, that it was the same thread size, and put the lens back 90 clockwise, allowing the shutter release to be up, rather than to the left side, looking from the front, where it was conflicting with the frame.

Is there any reason this should not be done?

There is no reason not to clock the shutter to suit you.